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Bull Exp Biol Med. 2017 Oct;163(6):710-713. doi: 10.1007/s10517-017-3886-8. Epub 2017 Oct 24.

Role of β2-Adrenoreceptors in Adrenergic Anti-Inflammatory Mechanism in Sepsis.

Author information

1
REAVIZ Saratov Medical University, Saratov, Russia. pfzabrodsky@gmail.com.
2
REAVIZ Saratov Medical University, Saratov, Russia.

Abstract

Experiments on random-bred albino mice showed that of β2-adrenoreceptor agonist hexaprenaline sulfate significantly reduced mortality of mice from experimental sepsis (intraperitoneal administration of E. coli) in 4 and 24 h after modeling by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The antagonist of β2AR ICI-118,551 eliminated this effect.

KEYWORDS:

adrenergic anti-inflammatory mechanism; pro-inflammatory cytokines; sepsis; β2-adrenoceptors

PMID:
29063336
DOI:
10.1007/s10517-017-3886-8
[Indexed for MEDLINE]

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