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Afr J Lab Med. 2011 Dec 15;1(1):5. doi: 10.4102/ajlm.v1i1.5. eCollection 2012.

Immunohaematological reference values for HIV-negative healthy adults in Botswana.

Author information

1
National Health Laboratory, Gaborone, Botswana.
2
Botswana-Harvard AIDS Institute Partnership (BHP), Princess Marina Hospital, Gaborone, Botswana.
3
Safety Monitoring in International Laboratories (SMILE), Johns Hopkins University, Baltimore, Maryland, United States.
4
Harvard School of Public Health, Boston, Massachusetts, United States.
5
Department of Clinical Services, Ministry of Health, Gaborone, Botswana.
6
Department of HIV/AIDS Prevention and Care, Ministry of Health, Gaborone, Botswana.

Abstract

BACKGROUND:

Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks.

OBJECTIVES:

The aim of this study was to determine the means, medians, 2.5th and 97.5th percentile reference intervals, for normal immunohaematological values in healthy adults in Botswana.

METHOD:

A total of 261 healthy participants comprising 126 men (48%) and 135 (52%) women were enrolled in the southern part of Botswana, and immunological and haematological laboratory parameters were measured.

RESULTS:

The mean age was 28.8 (95% Confidence Interval [CI] 27.7-29.8) years, with a median of 27 years and a range 18-66 years. The mean haemoglobin level was significantly lower for women (12.4 g/dL; 95% CI 12.1% - 12.7%) than men (15.1 g/dL; 95% CI 14.9% - 15.3%). The women's haemoglobin reference values (9.0 g/dL - 15.0 g/dL) levels were lower than observed in predominantly White populations (12.0 g/dL - 16.0 g/dL), but comparable with regional consensus reference intervals (9.5 g/dL - 15.8 g/dL) recently defined for East and Southern Africa.

CONCLUSION:

The established values provide an important tool for patient management and could influence decisions on inclusion of participants and adverse events in clinical trials conducted locally.

PMID:
29062725
PMCID:
PMC5644526
DOI:
10.4102/ajlm.v1i1.5

Conflict of interest statement

The authors declare that they have no financial or personal relationship(s) which may have influenced them inappropriately in writing this article.

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