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Infect Immun. 2017 Dec 19;86(1). pii: e00601-17. doi: 10.1128/IAI.00601-17. Print 2018 Jan.

Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice.

Gao X1,2, Xie Q1,3,4, Kong P1, Liu L1, Sun S1, Xiong B1, Huang B1, Yan L2,5, Sheng J6, Xiang H7,3,4.

Author information

1
School of Life Sciences, Jilin University, Changchun Jilin, People's Republic of China.
2
Pu'er Institute of Pu-er Tea, Pu'er Yunnan, People's Republic of China.
3
National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun Jilin, People's Republic of China.
4
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Jilin, People's Republic of China.
5
College of Pu-er Tea, West Yunnan University of Applied Science, Pu'er Yunnan, People's Republic of China.
6
Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming Yunnan, People's Republic of China Shengj@ynau.edu.cn hyxiang@jlu.edu.cn.
7
School of Life Sciences, Jilin University, Changchun Jilin, People's Republic of China Shengj@ynau.edu.cn hyxiang@jlu.edu.cn.

Abstract

Postfermented Pu-erh tea (PE) protects against metabolic syndrome (MS), but little is known regarding its underlying mechanisms. Animal experiments were performed to determine whether the gut microbiota mediated the improvement in diet-induced MS by PE and its main active components (PEAC). We confirmed that PE altered the body composition and energy efficiency, attenuated metabolic endotoxemia and systemic and multiple-tissue inflammation, and improved the glucose and lipid metabolism disorder in high-fat diet (HFD)-fed mice via multiple pathways. Notably, PE promoted the lipid oxidation and browning of white adipose tissue (WAT) in HFD-fed mice. Polyphenols and caffeine (CAF) played critical roles in improving these parameters. Meanwhile, PE remodeled the disrupted intestinal homeostasis that was induced by the HFD. Many metabolic changes observed in the mice were significantly correlated with alterations in specific gut bacteria. Akkermansia muciniphila and Faecalibacterium prausnitzii were speculated to be the key gut bacterial links between the PEAC treatment and MS at the genus and species levels. Interestingly, A. muciniphila administration altered body composition and energy efficiency, promoted the browning of WAT, and improved the lipid and glucose metabolism disorder in the HFD-fed mice, whereas F. prausnitzii administration reduced the HFD-induced liver and intestinal inflammatory responses. In summary, polyphenol- and CAF-rich PE improved diet-induced MS, and this effect was associated with a remodeling of the gut microbiota.

KEYWORDS:

Akkermansia muciniphila; fat browning; gut microbiota; inflammatory responses; metabolic endotoxemia; metabolic syndrome

PMID:
29061705
PMCID:
PMC5736808
DOI:
10.1128/IAI.00601-17
[Indexed for MEDLINE]
Free PMC Article

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