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BMJ Open. 2017 Oct 22;7(10):e014706. doi: 10.1136/bmjopen-2016-014706.

Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies.

Author information

1
Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China.
2
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Abstract

BACKGROUND:

There is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose-response relationship is still unclear.

OBJECTIVE:

To quantitatively investigate the relationship between dementia and PA.

DESIGN:

PubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on the dose-response relationship using two stage generalised least squares regression.

RESULTS:

The primary analysis exhibited a dose-response trend for all-cause dementia (ACD), Alzheimer's disease (AD) but not for vascular dementia (VD). In the dose-response analysis, either ACD (ptrend <0.005; pnon-linearity=0.87) or AD (p trend <0.005; pnon-linearity=0.10) exhibited a linear relationship with leisure time PA (LTPA) over the observed range (0-2000 kcal/week or 0-45 metabolic equivalent of task hours per week (MET-h/week)). Specifically, for every 500 kcal or 10 MET-h increase per week, there was, on average, 10% and 13% decrease in the risk of ACD and AD, respectively.

CONCLUSIONS:

We have reported, for the first time, the dose-response relationship between LTPA and dementia, further supporting the international PA guideline from the standpoint of dementia prevention.

KEYWORDS:

alzheimer; dementia; dose-response; physical Activity

PMID:
29061599
PMCID:
PMC5665289
DOI:
10.1136/bmjopen-2016-014706
[Indexed for MEDLINE]
Free PMC Article

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