Format

Send to

Choose Destination
Am J Surg. 2018 Jan;215(1):125-130. doi: 10.1016/j.amjsurg.2017.09.030. Epub 2017 Oct 7.

Liver resection for metastases not of colorectal, neuroendocrine, sarcomatous, or ovarian (NCNSO) origin: A multicentric study.

Author information

1
Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Visceral Surgery, Lausanne University Hospital CHUV, Switzerland.
2
Department of Surgery and Transplantation, University Hospital Zurich, Zürich, Switzerland.
3
Department of Surgery and Transplantation, University Hospital Zurich, Zürich, Switzerland; Department of Surgery - Transplant Surgery, Rush University Medical Center, Chicago, IL, USA; Cantonal Hospital Winterthur, Kanton Zurich, Switzerland.
4
Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA; Division of Urology, Department of Surgery and Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.
5
Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA.
6
Divisions of Digestive and Transplant Surgery, Department of Surgery, Geneva University Hospital and Faculty of Medicine, Switzerland.
7
Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: myron.schwartz@mountsinai.org.

Abstract

BACKGROUND:

Liver resection is a well-established treatment for colorectal, neuroendocrine and sarcomatous metastases but remains ill-defined for metastases from other primary sites. This study aimed to analyze the outcomes of hepatic resection for metastases not of colorectal, neuroendocrine, sarcomatous, or ovarian (NCNSO) origin and to identify predictors of outcome.

METHODS:

Retrospective analysis of patients undergoing resection for NCNSO metastases in three western centers. Patients were analyzed according to the primary cancer. Outcomes were recurrence and survival.

RESULTS:

We analyzed 188 patients, divided in: gastrointestinal (59), breast (59) and "others" (70). Median time to recurrence was 15.3 months, while median survival was 52 months. Survival at 1, 3, and 5 years was 78%, 60.4% and 47.8%, respectively. In term of prognostic factors, metastases >35 mm from gastrointestinal tumors were associated with lower survival (p = 0.029) and age>60 years was associated with better survival in breast metastases (p = 0.018).

CONCLUSIONS:

Liver resection for NCNSO metastases is feasible and results in long-term survival are similar to colorectal metastases. In gastrointestinal metastases, size (<35 mm) could be used to select patients.

KEYWORDS:

Liver resection; Non-colorectal; Non-neuroendocrine; Non-ovarian; Non-sarcomatous

PMID:
29061283
DOI:
10.1016/j.amjsurg.2017.09.030
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center