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Clin Invest Med. 2017 Oct 19;40(5):E188-E199. doi: 10.25011/cim.v40i5.28624.

Glucagon-like peptide-1 levels and dipeptidyl peptidase-4 activity in type 2 diabetes.

Author information

1
University of Biruni, Medical Faculty, Department of Internal Medicine, Medicine Hospital, Istanbul, Turkey. email@email.com.

Abstract

PURPOSE:

Hyperglycemia is the major risk factor for microvascular complications in type 2 diabetes mellitus (T2DM) patients. This randomized controlled clinical trial aimed to investigate T2DM patients with microvascular complications with regard to possible relations among serum clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) activities.

METHODS:

Subject groups were defined as follows: T2DM without complications (n=25, F/M=9/16, age 53.9±11.1 years); T2DM+Retinopathy (n=25, F/M=13/12, age 63.8±7.1 years); T2DM+Nephropathy (n=25, F/M=13/12, age 58.7±14.4 years); T2DM+Neuropathy (n=25, F/M=15/10, age 63.2±9.6 years); and healthy control subjects (HC) (n=25). CLU, amylin, SFRP-4, DPP-4 and GLP-1 (total and active) activities were measured and compared in blood samples from type 2 diabetic patients with and without microvascular complications.

RESULTS:

Significantly lower levels of DPP-4 and GLP-1total (P.

PMID:
29061224
DOI:
10.25011/cim.v40i5.28624
[Indexed for MEDLINE]

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