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Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Oct 10;38(10):1415-1418. doi: 10.3760/cma.j.issn.0254-6450.2017.10.024.

[Influence of intrahepatic cholestasis during pregnancy on the incidence of preterm birth].

[Article in Chinese; Abstract available in Chinese from the publisher]

Author information

Department of Hygienic Microbiology, School of Public Health; Department of Epidemiology, School of Public Health.
Fudan University, Shanghai 200032, China; Department of Laboratory, Anqing Municipal Hospital, Anqing 246003, China.
Department of Obstetrics and Gynecology, Anqing Municipal Hospital, Anqing 246003 China.
Department of Hygienic Microbiology, School of Public Health.
Department of Hygienic Microbiology, School of Public Health; Key Laboratory for Public Health Safety, Ministry of Education-School of Public Health; Key Laboratory for Health Technology Assessment, National Commission of Health and Family Planning; The Innovation Center for Social Risk Governance in Health, Shanghai 200032, China.


in English, Chinese

Objective: Intrahepatic cholestasis during pregnancy (ICP) and its relation to incidence of preterm birth (PTB) were under study. Methods: A prospective cohort study was carried out that including all the hospitalized pregnant women with live singleton births, from January 2014 to March 2015 in Anqing Municipal Hospitals. Informed consent was followed in every pregnant woman with related demographic information collected through questionnaire and hospital electronic medical record system. Both univariate and multi-variate statistical methods were used to analyze the relations between ICP and incidence of PTB. Results: A total of 2 758 pregnant women were included in this study. The incidence proportions of ICP and PTB appeared as 7.25% and 16.28% respectively. Results from the logistic regression analysis showed that ICP increased the risk of both overall PTB (RR=2.33, 95%CI: 1.67-3.25) and medically indicated PTB (RR=8.46, 95%CI: 5.45-13.12), but not the spontaneous PTB (RR=0.94, 95%CI: 0.57-1.54). Conclusion: ICP seemed to have increased the risk on medically indicated PTB but not the spontaneous PTB.


Cohort study; Intrahepatic cholestasis of pregnancy; Preterm birth

[Indexed for MEDLINE]

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