Format

Send to

Choose Destination
Elife. 2017 Oct 23;6. pii: e30135. doi: 10.7554/eLife.30135.

Control of plant cell fate transitions by transcriptional and hormonal signals.

Author information

1
Department of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany.
2
Institute of Applied Mathematics, Heidelberg University, Heidelberg, Germany.
3
Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany.
4
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, San Diego, United States.
5
Bioquant Center, Heidelberg University, Heidelberg, Germany.
#
Contributed equally

Abstract

Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) genes in regulating developmental trajectories of shoot stem cells in Arabidopsis thaliana. Our work reveals that HEC function stabilizes cell fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem cell differentiation. Importantly, this activity is concomitant with the local modulation of cellular responses to cytokinin and auxin, two key phytohormones regulating cell behaviour. Mechanistically, we show that HEC factors transcriptionally control and physically interact with MONOPTEROS (MP), a key regulator of auxin signalling, and modulate the autocatalytic stabilization of auxin signalling output.

KEYWORDS:

A. thaliana; HECATE1; auxin; cell fate; cytokinin; developmental biology; plant biology; shoot meristem; stem cells

PMID:
29058667
PMCID:
PMC5693117
DOI:
10.7554/eLife.30135
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for eLife Sciences Publications, Ltd Icon for PubMed Central
Loading ...
Support Center