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Hum Brain Mapp. 2018 Jan;39(1):459-471. doi: 10.1002/hbm.23855. Epub 2017 Oct 23.

Predicting auditory feedback control of speech production from subregional shape of subcortical structures.

Tang X1,2,3,4, Chen N5, Zhang S5, Jones JA6, Zhang B5, Li J1,4, Liu P5, Liu H5,7.

Author information

1
Sun Yat-sen University-Carnegie Melon University (SYSU-CMU) Joint Institute of Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
2
Sun Yat-sen University-Carnegie Melon University (SYSU-CMU) Shunde International Joint Research Institute, Shunde, 528300, China.
3
School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou, 510006, China.
4
Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, 15213, Pennsylvania.
5
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
6
Psychology Department and Laurier Centre for Cognitive Neuroscience, Wilfrid Laurier University, Waterloo, Ontario, N2L 3C5, Canada.
7
Guangdong Provincial Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.

Abstract

Although a growing body of research has focused on the cortical sensorimotor mechanisms that support auditory feedback control of speech production, much less is known about the subcortical contributions to this control process. This study examined whether subregional anatomy of subcortical structures assessed by statistical shape analysis is associated with vocal compensations and cortical event-related potentials in response to pitch feedback errors. The results revealed significant negative correlations between the magnitudes of vocal compensations and subregional shape of the right thalamus, between the latencies of vocal compensations and subregional shape of the left caudate and pallidum, and between the latencies of cortical N1 responses and subregional shape of the left putamen. These associations indicate that smaller local volumes of the basal ganglia and thalamus are predictive of slower and larger neurobehavioral responses to vocal pitch errors. Furthermore, increased local volumes of the left hippocampus and right amygdala were predictive of larger vocal compensations, suggesting that there is an interplay between the memory-related subcortical structures and auditory-vocal integration. These results, for the first time, provide evidence for differential associations of subregional morphology of the basal ganglia, thalamus, hippocampus, and amygdala with neurobehavioral processing of vocal pitch errors, suggesting that subregional shape measures of subcortical structures can predict behavioral outcome of auditory-vocal integration and associated neural features. Hum Brain Mapp 39:459-471, 2018.

KEYWORDS:

auditory feedback; sensorimotor integration; shape analysis; speech production; subcortical morphology

PMID:
29058356
DOI:
10.1002/hbm.23855
[Indexed for MEDLINE]

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