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Bioessays. 2017 Dec;39(12). doi: 10.1002/bies.201700124. Epub 2017 Oct 23.

Broad Chromatin Domains: An Important Facet of Genome Regulation.

Author information

1
The Gurdon Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QN, United Kingdom.

Abstract

Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans.

KEYWORDS:

H3K27me3; PRC2; chromatin domain; histone modifications

PMID:
29058338
DOI:
10.1002/bies.201700124
[Indexed for MEDLINE]

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