Format

Send to

Choose Destination
Sci Rep. 2017 Oct 20;7(1):13720. doi: 10.1038/s41598-017-13151-3.

Prognostic values of red blood cell distribution width, platelet count, and red cell distribution width-to-platelet ratio for severe burn injury.

Author information

1
Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
2
Department of Burns, Rui Jin Hospital, Shanghai Jiao Tong University, Shanghai, China.
3
Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China. xulinchen@126.com.

Abstract

Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have been associated with inflammatory activity and adverse outcomes in many diseases. This study has aimed to investigate the association between these indicators and the mortality rate of severe burn patients. From 2008 to 2014, 610 cases of severe burn patients from two burn centers in eastern China were enrolled in this study. Eighty-eight patients died within 90 days after admission. The RDW, PLT, and RPR were studied through Cox regression analysis on the 3rd and 7th day. The RDW, PLT, and RPR values on the 3rd and 7th day were significantly associated with the outcomes of severe burn patients (P < 0.01). High RPR was significantly associated with a 90-day mortality rate at the two time points. However, the RDW and PLT did not provide independent predictive values. Our results indicated that the RPR values on the 3rd and 7th day were associated with the mortality rates of severe burn patients (P < 0.01). Meanwhile, the RDW and PLT values at these time points failed to provide independent values for burn mortality prediction. Thus, the RPR can serve as an independent and novel marker for mortality rates prediction in severe burn patients.

PMID:
29057939
PMCID:
PMC5651922
DOI:
10.1038/s41598-017-13151-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center