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Alzheimers Dement. 2017 Dec;13(12):1410-1413. doi: 10.1016/j.jalz.2017.09.010. Epub 2017 Oct 19.

Alzheimer's Disease Sequencing Project discovery and replication criteria for cases and controls: Data from a community-based prospective cohort study with autopsy follow-up.

Author information

1
Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: pcrane@uw.edu.
2
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
3
Department of Pathology, Stanford University, Stanford, CA, USA.
4
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Abstract

INTRODUCTION:

The Alzheimer's Disease Sequencing Project (ADSP) used different criteria for assigning case and control status from the discovery and replication phases of the project. We considered data from a community-based prospective cohort study with autopsy follow-up where participants could be categorized as case, control, or neither by both definitions and compared the two sets of criteria.

METHODS:

We used data from the Adult Changes in Thought (ACT) study including Diagnostic and Statistical Manual-IV criteria for dementia status, McKhann et al. criteria for clinical Alzheimer's disease, and Braak and Consortium to Establish a Registry for AD findings on neurofibrillary tangles and neuritic plaques to categorize the 621 ACT participants of European ancestry who died and came to autopsy. We applied ADSP discovery and replication definitions to identify controls, cases, and people who were neither controls nor cases.

RESULTS:

There was some agreement between the discovery and replication definitions. Major areas of discrepancy included the finding that only 40% of the discovery sample controls had sufficiently low levels of neurofibrillary tangles and neuritic plaques to be considered controls by the replication criteria and the finding that 16% of the replication phase cases were diagnosed with non-AD dementia during life and thus were excluded as cases for the discovery phase.

CONCLUSIONS:

These findings should inform interpretation of genetic association findings from the ADSP. Differences in genetic association findings between the two phases of the study may reflect these different phenotype definitions from the discovery and replication phase of the ADSP.

KEYWORDS:

Alzheimer's disease; Genetics; Phenotype

PMID:
29055816
PMCID:
PMC5723534
[Available on 2018-12-01]
DOI:
10.1016/j.jalz.2017.09.010
[Indexed for MEDLINE]

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