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Auris Nasus Larynx. 2018 Aug;45(4):783-790. doi: 10.1016/j.anl.2017.09.013. Epub 2017 Oct 18.

Correlation between computed tomography imaging and histopathology in pleomorphic adenoma of parotid gland.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University, Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea.
2
Department of Otorhinolaryngology-Head and Neck Surgery, CHA Medical Center, CHA University, Seongnam, Republic of Korea.
3
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
4
Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea.
5
Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
6
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
7
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea; Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul National University Hospital, Seoul, Republic of Korea.
8
Department of Otorhinolaryngology, Seoul Metropolitan Boramae Medical Center, Seoul, Republic of Korea.
9
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea; Sensory Organ Research Institute, Seoul National University Medical Research Center, Seoul National University Hospital, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Clinical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: mwsung@snu.ac.kr.

Abstract

OBJECTIVE:

The purpose of this study was to correlate the CT imaging features and histopathological findings of pleomorphic adenomas (PA), and also try to identify its clinical significance.

METHODS:

Totally 262 PAs in the parotid gland including 18 recurrent cases were retrospectively reviewed with preoperative CT and pathologic slides. Each pathologic slide was reviewed by two pathologists to calculate mean value of epithelial/mesenchymal component, and the results were correlated with features of CT scans.

RESULTS:

PAs showing high contrast enhancement were correlated with high proportion of epithelial components in histopathologic findings. PAs with smooth border tend to have high proportion of epithelial components. The margin on CT imaging did not consisted with pathologic margin of resected specimens. In recurrent PAs, there was a significant difference on CT contrast enhancement, not in proportion of epithelial component.

CONCLUSION:

The histopathology and CT imaging features of PAs were variable, but we can find the correlation of epithelial component and CT contrast enhancement. Further large scale study would be expected to identify the clinical significance of CT imaging features and histopathologic findings of PAs.

KEYWORDS:

Computed tomography; Histopathology; Parotid gland; Pleomorphic adenoma

PMID:
29055657
DOI:
10.1016/j.anl.2017.09.013
[Indexed for MEDLINE]

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