Format

Send to

Choose Destination
J Chem Phys. 2017 Oct 21;147(15):152715. doi: 10.1063/1.4997377.

Multifunctional energy landscape for a DNA G-quadruplex: An evolved molecular switch.

Author information

1
University Chemical Laboratories, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
2
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 612 65 Brno, Czech Republic.
3
Laboratoire de Biochimie Théorique UPR 9080 CNRS, Université Paris Diderot, Sorbonne Paris Cité, IBPC 13 Rue Pierre et Marie Curie, 75005 Paris, France.

Abstract

We explore the energy landscape for a four-fold telomere repeat, obtaining interconversion pathways between six experimentally characterised G-quadruplex topologies. The results reveal a multi-funnel system, with a variety of intermediate configurations and misfolded states. This organisation is identified with the intrinsically multi-functional nature of the system, suggesting a new paradigm for the classification of such biomolecules and clarifying issues regarding apparently conflicting experimental results.

PMID:
29055346
DOI:
10.1063/1.4997377
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Institute of Physics
Loading ...
Support Center