Format

Send to

Choose Destination
Z Naturforsch C. 2018 Jan 26;73(1-2):49-57. doi: 10.1515/znc-2017-0140.

N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp. MII.

Author information

1
Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, Universitätsstraße 25, D-33501 Bielefeld, Germany.
2
Centrum für Biotechnologie (CeBiTec), Bielefeld University, Universitätsstraße 27, D-33615 Bielefeld, Germany.
3
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.

Abstract

In the course of our screening program for new bioactive compounds, a naturally new 18-membered macrolide antibiotic, N-acetylborrelidin B (1) along with borrelidin (2) were obtained from the marine Streptomyces mutabilis sp. MII. The strain was isolated from a sediment sample collected in the Red Sea at the Hurghada Coast and characterized taxonomically. Additional nine diverse bioactive compounds were reported: 6-prenyl-indole-3-acetonitrile (3), sitosteryl-3β-d-glucoside, campesterol, ferulic acid, linoleic acid methyl ester, linoleic acid, N-acetylanthranilic acid, indole 3-acetic acid methyl ester, indole 3-carboxylic acid, and adenosine. Structure 1 was confirmed by in-depth NMR studies and by mass spectra, and comparison with related literature data. The antimicrobial activity of the strain extract and compounds 1 and 2 were studied using a panel of pathogenic microorganisms. The in vitro cytotoxicity of compounds 1 and 2 as well as the crude extract were tested against the human cervix carcinoma cell line (KB-3-1).

KEYWORDS:

N-acetylborrelidin B; Streptomyces mutabilis sp. MII; biological activity; taxonomy

PMID:
29055178
DOI:
10.1515/znc-2017-0140

Supplemental Content

Full text links

Icon for Sheridan PubFactory
Loading ...
Support Center