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Br J Pharmacol. 2017 Dec;174 Suppl 1:S1-S16. doi: 10.1111/bph.13882.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

Collaborators (155)

Abbracchio MP, Aldrich R, Al-Hosaini K, Arumugam TV, Attali B, Bäck M, Barnes NM, Bathgate R, Beart PM, Becirovic E, Bettler B, Biel M, Birdsall NJ, Blaho V, Boison D, Bräuner-Osborne H, Bröer S, Bryant C, Burnstock G, Calo G, Catterall WA, Ceruti S, Chan SL, Chandy KG, Chazot P, Chiang N, Chun JJ, Chung JJ, Clapham DE, Clapp L, Connor MA, Cox HM, Davies P, Dawson PA, Decaen P, Dent G, Doherty P, Douglas SD, Dubocovich ML, Fong TM, Fowler CJ, Frantz A, Fuller P, Fumagalli M, Futerman AH, Gainetdinov RR, Gershengorn MA, Goldin A, Goldstein S, Goudet C, Gregory K, Grissmer S, Gundlach AL, Hagenbuch B, Hamann J, Hammond JR, Hancox JC, Hanson J, Hanukoglu I, Hay DL, Hobbs AJ, Hollenberg AN, Holliday ND, Hoyer D, Ijzerman AP, Inui KI, Irving AJ, Ishii S, Jacobson KA, Jan LY, Jarvis MF, Jensen R, Jockers R, Kaczmarek LK, Kanai Y, Karnik S, Kellenberger S, Kemp S, Kennedy C, Kerr ID, Kihara Y, Kukkonen J, Larhammar D, Leach K, Lecca D, Leeman S, Leprince J, Lolait SJ, Macewan D, Maguire JJ, Marshall F, Mazella J, Mcardle CA, Michel MC, Miller LJ, Mitolo V, Mizuno H, Monk PN, Mouillac B, Murphy PM, Nahon JL, Nerbonne J, Nichols CG, Norel X, Offermanns S, Palmer LG, Panaro MA, Papapetropoulos A, Perez-Reyes E, Pertwee RG, Pintor S, Pisegna JR, Plant LD, Poyner DR, Prossnitz ER, Pyne S, Ramachandran R, Ren D, Rondard P, Ruzza C, Sackin H, Sanger G, Sanguinetti MC, Schild L, Schiöth H, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Slesinger PA, Snutch TP, Sobey CG, Stewart G, Stoddart LA, Summers RJ, Szabo C, Thwaites D, Toll L, Trimmer JS, Tucker S, Vaudry H, Verri T, Vilargada JP, Waldman SA, Ward DT, Waxman SG, Wei AD, Willars GB, Wong SS, Woodruff TM, Wulff H, Ye RD, Yung Y, Zajac JM.

Author information

1
School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
2
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
3
Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
4
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK.
5
Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, United Kingdom.
6
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
7
Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria 3052, Australia.
8
Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.
9
PIQUR Therapeutics, Basel, 4057, Switzerland.
10
Spedding Research Solutions SARL, Le Vésinet, 78110, France.
11
Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria.

Abstract

The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

PMID:
29055037
PMCID:
PMC5650665
DOI:
10.1111/bph.13882
[Indexed for MEDLINE]
Free PMC Article

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