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Colloids Surf B Biointerfaces. 2018 Jan 1;161:73-82. doi: 10.1016/j.colsurfb.2017.10.035. Epub 2017 Oct 12.

Surface modification of polyisobutylene via grafting amino acid-based poly (acryloyl-6-aminocaproic acid) as multifunctional material.

Author information

1
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China.
2
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
3
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China. Electronic address: jjin@ciac.ac.cn.
4
Department of Infection, The Affiliated Hospital of QingDao University, QingDao, 266003, PR China.
5
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China. Electronic address: wjiang@ciac.ac.cn.

Abstract

Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA was activated to immobilize functional protein-Concanavalin A (Con A). The obtained Con A-coupled microdomains could further capture erythrocytes. This method developed a platform on commercial PIB surface via amino acid-based polymer brushes which had a promising application in drug delivery and disease diagnosis.

KEYWORDS:

Concanavalin A; Erythrocyte; Hemocompatibility; Poly (acryloyl-6-aminocaproic acid); Polyisobutylene

PMID:
29054046
DOI:
10.1016/j.colsurfb.2017.10.035
[Indexed for MEDLINE]

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