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Cell. 2017 Oct 19;171(3):501-502. doi: 10.1016/j.cell.2017.10.006.

Transforming Lipoxygenases: PE-Specific Enzymes in Disguise.

Author information

1
Department of Biological Sciences, Columbia University, 550 West 120(th) Street, MC4846, New York, NY 10027, USA.
2
Department of Biological Sciences, Columbia University, 550 West 120(th) Street, MC4846, New York, NY 10027, USA; Department of Chemistry, Columbia University, 550 West 120(th) Street, MC4846, New York, NY 10027, USA. Electronic address: bstockwell@columbia.edu.

Abstract

In this issue of Cell, Wenzel et al. solve a long-standing mystery regarding how damage to cell membranes occurs during ferroptosis, an iron-dependent form of regulated cell death. They found that lipoxygenases are like Transformer toys, being converted from one enzyme type to another in the presence of the protein PEBP1.

PMID:
29053966
PMCID:
PMC5960801
DOI:
10.1016/j.cell.2017.10.006
[Indexed for MEDLINE]
Free PMC Article

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