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PLoS One. 2017 Oct 20;12(10):e0186521. doi: 10.1371/journal.pone.0186521. eCollection 2017.

Heart rate variability and baroreceptor reflex sensitivity in early- versus late-onset preeclampsia.

Author information

1
Department of Physiology, Medical University of Graz, Graz, Austria.
2
Department of Medical Engineering, Graz University of Technology, Graz, Austria.
3
Department of Psychology, Biological Psychology Unit, University of Graz, Graz, Austria.
4
Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.
5
Department of Perinatology, Division of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
6
Department of Obstetrics and Gynecology, Clinical Center, Klagenfurt, Austria.

Abstract

OBJECTIVE:

To determine whether there are differences in autonomic nervous system function in early- versus late-onset preeclampsia.

METHODS:

Matched case-control study. Cases were defined as singleton pregnancies with preeclampsia at < 34+0 weeks of gestation (early-onset preeclampsia) and ≥ 34+0 weeks of gestation (late-onset preeclampsia). For each case in each of the preeclampsia subgroups, three "control"uncomplicated singleton pregnancies were matched by maternal age, height, and week of gestation. Blood pressure and heart rate were measured continuously for 30 minutes in each participant. Baroreceptor reflex sensitivity (assessed using sequence technique), time and frequency domain heart rate variability measures, as SDNN, RMSSD, LFRRI, HFRRI and LF/HFRRI of R-R intervals, were compared between groups (p<0.05 significant).

RESULTS:

24 women with preeclampsia (10 with early-onset and 14 with late-onset preeclampsia) and 72 controls were included in the study. SDNN, RMSSD and HFRRI were significantly higher in the late-onset preeclampsia group compared to gestational age matched controls (p = 0.033, p = 0.002 and p = 0.018, respectively). No significant differences in SDNN RMSSD and HFRRI between early-onset preeclampsia group and gestational age matched controls were observed (p = 0.304, p = 0.325 and p = 0.824, respectively). Similarly, baroreceptor reflex sensitivity was higher in late-onset preeclampsia compared to controls at ≥ 34 weeks (p = 0.037), but not different between early-onset preeclampsia compared to controls at < 34 weeks (p = 0.50).

CONCLUSIONS:

Heart rate variability and baroreceptor reflex sensitivity are increased in late- but not early-onset preeclampsia compared to healthy pregnancies. This indicates a better autonomic nervous system mediated adaptation to preeclampsia related cardiovascular changes in late-onset disease.

PMID:
29053723
PMCID:
PMC5650147
DOI:
10.1371/journal.pone.0186521
[Indexed for MEDLINE]
Free PMC Article

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