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Nat Commun. 2017 Oct 20;8(1):1062. doi: 10.1038/s41467-017-01020-6.

Ets transcription factor GABP controls T cell homeostasis and immunity.

Author information

1
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
2
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
3
Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
4
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. lim@mskcc.org.

Abstract

Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.

PMID:
29051483
PMCID:
PMC5648787
DOI:
10.1038/s41467-017-01020-6
[Indexed for MEDLINE]
Free PMC Article

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