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Int J Pharm. 2018 Jan 15;535(1-2):325-332. doi: 10.1016/j.ijpharm.2017.10.037. Epub 2017 Oct 16.

Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing.

Author information

1
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
2
Discipline Construction and Development Planning Section, Shenyang Medical College, 146 Huanghe North Street, Shenyang 110034, China.
3
Department of Pharmaceutical Information, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016, China.
4
Shanghai Jingxin Biology & Pharmaceutical Co., Ltd., 150 Copernicus Road, Zhangjiang High Technology Park, Shanghai, 201210, China.
5
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: yangxg123@163.com.
6
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: pppwwwsss@163.com.

Abstract

Three dimensional (3D) extrusion-based printing is a paste-based rapid prototyping process, which is capable of building complex 3D structures. The aim of this study was to explore the feasibility of 3D extrusion-based printing as a pharmaceutical manufacture technique for the fabrication of gastro-floating tablets. Novel low-density lattice internal structure gastro-floating tablets of dipyridamole were developed to prolong the gastric residence time in order to improve drug release rate and consequently, improve bioavailability and therapeutic efficacy. Excipients commonly employed in the pharmaceutical study could be efficiently applied in the room temperature 3D extrusion-based printing process. The tablets were designed with three kinds of infill percentage and prepared by hydroxypropyl methylcellulose (HPMC K4M) and hydroxypropyl methylcellulose (HPMC E15) as hydrophilic matrices and microcrystalline cellulose (MCC PH101) as extrusion molding agent. In vitro evaluation of the 3D printed gastro-floating tablets was performed by determining mechanical properties, content uniformity, and weight variation. Furthermore, re-floating ability, floating duration time, and drug release behavior were also evaluated. Dissolution profiles revealed the relationship between infill percentage and drug release behavior. The results of this study revealed the potential of 3D extrusion-based printing to fabricate gastro-floating tablets with more than 8h floating process with traditional pharmaceutical excipients and lattice internal structure design.

KEYWORDS:

3D printing; Gastro-floating; Lattice structure; Personalized medicine; Sustained release

PMID:
29051121
DOI:
10.1016/j.ijpharm.2017.10.037
[Indexed for MEDLINE]

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