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Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26861. Epub 2017 Oct 19.

Adolescents and young adults with brain tumors in the context of molecular advances in neuro-oncology.

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Department of Pediatric Hematology and Oncology, University Hospital Motol and 2nd Medical School, Charles University, Prague, Czech Republic.
Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Pediatric Hematology Oncology Department, Hospital Niño Jesús, Madrid, Spain.


Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age-dependent heterogeneity. Herein, we summarize the current state of the AYA population in neuro-oncology, specifically how biological advances can help personalize therapy for this unique group of patients.


adolescents and young adults; brain tumor; glioma; pediatric

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