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Ann N Y Acad Sci. 1988;537:435-42.

Neuroleptic binding to human brain receptors: relation to clinical effects.

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Department of Psychiatry, Mayo Clinic and Foundation, Rochester, Minnesota 55905.


Table 2 summarizes the potential clinical consequences of neurotransmitter receptor blockade by neuroleptics. These pharmacological effects of neuroleptics at receptors in brain and elsewhere in the body are likely responsible for therapeutic and certain adverse effects as well as some drug-drug interactions. Data presented here should allow the physician a rational basis for selecting neuroleptics to minimize these unwanted effects in patients.

[Indexed for MEDLINE]

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