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Phytother Res. 2018 Jan;32(1):94-102. doi: 10.1002/ptr.5953. Epub 2017 Oct 19.

Acute cardiovascular effects of bitter orange extract (p-synephrine) consumed alone and in combination with caffeine in human subjects: A placebo-controlled, double-blind study.

Author information

1
Department of Health and Exercise Science, The College of New Jersey, Ewing, NJ, 08628, USA.
2
School of Pharmacy and Health Professions, Creighton University, Omaha, NE, 68178, USA.

Abstract

The purpose was to examine cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects were given (in double-blind manner) either 103 mg of p-synephrine (S), 233 mg of caffeine +104 mg of p-synephrine (LC + S), 240 mg of caffeine (LC), 337 mg of caffeine +46 mg of p-synephrine (HC + S), 325 mg of caffeine (HC), or a placebo. The subjects sat quietly for 3 hr while heart rate (HR) and blood pressure were measured. Only HC + S and HC significantly increased mean systolic blood pressure (SBP) during the second hour and tended to increase mean SBP during the third hour. Mean diastolic blood pressure in S was significantly lower than the other trials during the first and second hours, and mean arterial pressure was significantly lower in S compared to the LC, LC + S, HC, and HC + S trials. No differences were observed in HR. Consumption of p-synephrine may acutely reduce diastolic blood pressure and mean arterial pressure and not affect SBP or HR during quiet sitting. The addition of p-synephrine to caffeine did not augment SBP or HR indicating that consumption of up to 104 mg of p-synephrine does not induce cardiovascular stress during quiet sitting.

KEYWORDS:

Citrus aurantium; blood pressure; caffeine; heart rate; mean arterial pressure; p-synephrine

PMID:
29047215
DOI:
10.1002/ptr.5953
[Indexed for MEDLINE]

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