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ChemPhotoChem. 2017 Mar;1(3):89-92. doi: 10.1002/cptc.201600044. Epub 2017 Feb 8.

Intramolecular Photogeneration of a Tyrosine Radical in a Designed Protein.

Author information

1
Dr. A. G. Tebo, Prof. V. L. Pecoraro, Department of Chemistry, University of Michigan, Ann Arbor, MI 48109 (USA).
2
Dr. A. Quaranta, Prof. A. Aukauloo, CEA Saclay, iBiTecS, Service de Bioénergétique Biologie Structurale et Mécanismes (SB2SM), Gif-sur-Yvette, 91191 (France).
3
Dr. C. Herrero, Prof. A. Aukauloo, Institut de Chimie Moléculaire et des Matériaux D'Orsay, Université Paris Sud, Université Paris Saclay, CNRS UMR 8182, 91405 Orsay Cedex (France).

Abstract

Long-distance biological electron transfer occurs through a hopping mechanism and often involves tyrosine as a high potential intermediate, for example in the early charge separation steps during photosynthesis. Protein design allows for the development of minimal systems to study the underlying principles of complex systems. Herein, we report the development of the first ruthenium-linked designed protein for the photogeneration of a tyrosine radical by intramolecular electron transfer.

KEYWORDS:

electron transfer; photochemistry; protein design; radicals; tyrosine

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