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Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R274-R281. doi: 10.1152/ajpregu.00216.2017. Epub 2017 Nov 14.

Sex differences in maternal gestational hypertension-induced sensitization of angiotensin II hypertension in rat offspring: the protective effect of estrogen.

Xue B1,2, Beltz TG1, Guo F1, Johnson AK1,3,4,2.

Author information

1
Department of Psychological and Brain Sciences, University of Iowa , Iowa City, Iowa.
2
François M. Abboud Cardiovascular Research Center, University of Iowa , Iowa City, Iowa.
3
Department of Pharmacology, University of Iowa , Iowa City, Iowa.
4
Department of Health and Human Physiology, University of Iowa , Iowa City, Iowa.

Abstract

Recent studies demonstrate that maternal hypertension during pregnancy sensitizes an angiotensin (ANG) II-induced increase in blood pressure (BP) in adult male offspring that was associated with upregulation of mRNA expression of several renin-angiotensin-aldosterone system (RAAS) components and NADPH oxidase in the lamina terminalis (LT) and paraventricular nucleus (PVN). The purpose of the present study was to test whether there are sex differences in the maternal hypertension-induced sensitization of ANG II hypertension, and whether sex hormones are involved in the sensitization process. Male offspring of hypertensive dams showed an enhanced hypertensive response to systemic ANG II when compared with male offspring of normotensive dams and to female offspring of either normotensive or hypertensive dams. Castration did not alter the hypertensive response to ANG II in male offspring. Intact female offspring had no upregulation of RAAS components and NADPH oxidase in the LT and PVN, whereas ovariectomy (OVX) upregulated mRNA expression of several RAAS components and NADPH oxidase in these nuclei and induced a greater increase in the pressor response to ANG II in female offspring of hypertensive dams compared with female offspring of normotensive dams. This enhanced increase in BP was partially attenuated by 17β-estradiol replacement in the OVX offspring of hypertensive dams. The results suggest that maternal hypertension induces a sex-specific sensitization of ANG II-induced hypertension and mRNA expression of brain RAAS and NADPH oxidase in offspring. Female offspring are protected from maternal hypertension-induced sensitization of ANG II hypertension, and female sex hormones are partially responsible for this protective effect.

KEYWORDS:

E2 replacement; gonadectomy; maternal hypertension; offspring; sensitization of angiotensin II hypertension

PMID:
29046315
PMCID:
PMC5867674
DOI:
10.1152/ajpregu.00216.2017
[Indexed for MEDLINE]
Free PMC Article

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