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J Diabetes Complications. 2017 Dec;31(12):1652-1657. doi: 10.1016/j.jdiacomp.2017.08.013. Epub 2017 Sep 1.

Interactions of TRAF6 and NLRX1 gene polymorphisms with environmental factors on the susceptibility of type 2 diabetes mellitus vascular complications in a southern Han Chinese population.

Author information

1
Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China.
2
Department of Pathogen biology, School of Medicine, Jinan University, Guangzhou 510632, China; Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, China. Electronic address: guangyangphd@gmail.com.
3
Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China; Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, China. Electronic address: jcxphd@gmail.com.
4
Department of Endocrine, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China. Electronic address: lihongnie@126.com.

Abstract

AIMS:

To evaluate the effects of TRAF6 and NLRX1 polymorphisms and their interactions with environmental factors on the susceptibility of type 2 diabetes mellitus (T2DM) vascular complications in a southern Han Chinese population.

METHODS:

Five single nucleotide polymorphisms (SNPs) were genotyped in a case-control study to estimate risk factors of T2DM vascular complications. Gene-gene and gene-environment interactions and haplotype associations were also estimated.

RESULTS:

The CA genotype of the NLRX1 rs4245191 was identified as a risk factor for T2DM macrovascular complications and diabetic cerebral infarction (OR=2.88, 95% CI=1.15-7.22, P=0.024; OR=4.00, 95% CI=1.04-15.38, P=0.043, respectively). A significantly lower T allele frequency in the TRAF6 rs16928973 was observed in T2DM patients with both microvascular and macrovascular complications compared with patients without any complication under the allelic model (T vs. C: OR=0.36, 95% CI=0.14-0.98, P=0.038). No significant differences in haplotypes, gene-gene interactions and gene-environment interactions were observed among T2DM vascular subgroup patients.

CONCLUSIONS:

Our study provides evidence that the NLRX1 rs4245191 polymorphisms influence the risk of T2DM macrovascular complications and diabetic cerebral infarction.

KEYWORDS:

Complication; Genetics; Interaction; NLRX1; T2DM; TRAF6

PMID:
29046236
DOI:
10.1016/j.jdiacomp.2017.08.013
[Indexed for MEDLINE]

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