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Gigascience. 2017 Oct 1;6(10):1-11. doi: 10.1093/gigascience/gix087.

Lipidomics profiling reveals the role of glycerophospholipid metabolism in psoriasis.

Zeng C1,2, Wen B1,2, Hou G1,2, Lei L3,4, Mei Z1,2, Jia X3,4, Chen X1,2, Zhu W3,4, Li J3,4, Kuang Y3,4, Zeng W3,4, Su J3,4, Liu S1,2, Peng C3,4, Chen X3,4.

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BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen, China, 518083.
China National GeneBank-Shenzhen, Jinsha Road, Dapeng District, Shenzhen, China, 518083.
Department of Dermatology, Xiangya Hospital, Central South University, Xiangya Road #87 Changsha, Hunan, China, 410008.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Xiangya Road #87 Changsha, Hunan, China, 410008.


Psoriasis is a common and chronic inflammatory skin disease that is complicated by gene-environment interactions. Although genomic, transcriptomic, and proteomic analyses have been performed to investigate the pathogenesis of psoriasis, the role of metabolites in psoriasis, particularly of lipids, remains unclear. Lipids not only comprise the bulk of the cellular membrane bilayers but also regulate a variety of biological processes such as cell proliferation, apoptosis, immunity, angiogenesis, and inflammation. In this study, an untargeted lipidomics approach was used to study the lipid profiles in psoriasis and to identify lipid metabolite signatures for psoriasis through ultra-performance liquid chromatography-tandem quadrupole mass spectrometry. Plasma samples from 90 participants (45 healthy and 45 psoriasis patients) were collected and analyzed. Statistical analysis was applied to find different metabolites between the disease and healthy groups. In addition, enzyme-linked immunosorbent assay was performed to validate differentially expressed lipids in psoriatic patient plasma. Finally, we identified differential expression of several lipids including lysophosphatidic acid (LPA), lysophosphatidylcholine (LysoPC), phosphatidylinositol (PI), phosphatidylcholine (PC), and phosphatidic acid (PA); among these metabolites, LPA, LysoPC, and PA were significantly increased, while PC and PI were down-regulated in psoriasis patients. We found that elements of glycerophospholipid metabolism such as LPA, LysoPC, PA, PI, and PC were significantly altered in the plasma of psoriatic patients; this study characterizes the circulating lipids in psoriatic patients and provides novel insight into the role of lipids in psoriasis.


Glycerophospholipid; Lipidomics; MS/MS; Metabolomics; Psoriasis

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