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Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12792. Epub 2017 Nov 27.

A cluster of scedosporiosis in lung transplant candidates and recipients: The Zurich experience and review of the literature.

Author information

1
Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
2
Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
3
Division of Trauma Surgery, University Hospital Zurich, Zurich, Switzerland.
4
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

Abstract

Scedosporium species are fungal pathogens increasingly recognized in cystic fibrosis (CF). They can cause multiresistant, life-threatening infections that are of particular concern in CF patients undergoing lung transplantation, as optimal treatment remains unclear. Here, we describe our Zurich experience of CF patients with Scedosporium infection. Disseminated infection occurred in one patient after transplantation and was successfully treated. We propose a step-by-step approach to treat candidates with colonization, and discuss our cases in the context of the current literature.

KEYWORDS:

Scedosporium ; cystic fibrosis; lung transplantation; scedosporiosis

PMID:
29044831
DOI:
10.1111/tid.12792
[Indexed for MEDLINE]

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