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Nat Rev Mol Cell Biol. 2017 Dec;18(12):717-727. doi: 10.1038/nrm.2017.101. Epub 2017 Oct 18.

Regulation of genome organization and gene expression by nuclear mechanotransduction.

Author information

1
Department of Electrical Engineering and Computer Science, Laboratory of Information and Decision Systems, Institute for Data, Systems and Society, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, USA.
2
Mechanobiology Institute, National University of Singapore, 119077 Singapore.
3
Italian Foundation for Cancer Research (FIRC) Institute of Molecular Oncology (IFOM), Milan 20139, Italy.

Abstract

It is well established that cells sense chemical signals from their local microenvironment and transduce them to the nucleus to regulate gene expression programmes. Although a number of experiments have shown that mechanical cues can also modulate gene expression, the underlying mechanisms are far from clear. Nevertheless, we are now beginning to understand how mechanical cues are transduced to the nucleus and how they influence nuclear mechanics, genome organization and transcription. In particular, recent progress in super-resolution imaging, in genome-wide application of RNA sequencing, chromatin immunoprecipitation and chromosome conformation capture and in theoretical modelling of 3D genome organization enables the exploration of the relationship between cell mechanics, 3D chromatin configurations and transcription, thereby shedding new light on how mechanical forces regulate gene expression.

PMID:
29044247
DOI:
10.1038/nrm.2017.101
[Indexed for MEDLINE]

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