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Drug Des Devel Ther. 2017 Oct 4;11:2921-2930. doi: 10.2147/DDDT.S122404. eCollection 2017.

Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy.

Author information

1
Department of Pharmacy Practice.
2
Department of Neurology, Creighton University Schools of Pharmacy and Medicine, Omaha, NE, USA.

Abstract

PURPOSE:

Perampanel is a first-in-class antiepileptic medication approved for the treatment of partial (focal) seizures, and as adjunctive treatment for primarily generalized tonic-clonic seizures. The pharmacology, efficacy data, adverse-effect profile, pharmacokinetics and place in therapy are reviewed.

SUMMARY:

Perampanel is indicated for use in patients with epilepsy who are 12 years of age or older. It is the first medication designed specifically to be a non-competitive antagonist at post-synaptic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors. Efficacy in refractory seizures has been established, and ongoing efficacy demonstrated by post-marketing data. The drug is completely absorbed, and exhibits a half-life that allows for once-daily administration in doses up to 12 mg/day. Drug interactions are minimal, but increased doses may be necessary when given with strong inducers of cytochrome P450 enzymes, including when perampanel is co-administered with other antiepileptics that exhibit this property. The most common adverse effects noted in both clinical trials and post-marketing are dizziness and somnolence. Psychiatric and behavioral adverse events have been documented in both adult and pediatric patients, including those with no corresponding diagnostic history.

CONCLUSION:

Perampanel is a novel adjunctive antiepileptic medication that is an effective option for adolescents and adults with partial seizures, and primarily generalized tonic-clonic seizures uncontrolled with other medications.

KEYWORDS:

focal seizures; fycompa; generalized seizures; partial seizures; perampanel

PMID:
29042752
PMCID:
PMC5634370
DOI:
10.2147/DDDT.S122404
[Indexed for MEDLINE]
Free PMC Article

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