Send to

Choose Destination
Arzneimittelforschung. 1988 Oct;38(10):1486-9.

New approach in bioavailability study of two formulations of ethyl loflazepate.

Author information

INSERM U 278, Faculty of Pharmacy, Marseille, France.


The disposition of ethyl loflazepate (Victan) was studied on 12 healthy male volunteers after administration of the two oral formulations of the drug: one 4-mg tablet and two 2-mg tablets according to an open crossover single dose comparison. A model-independent analysis and a model-dependent approach were used to treat experimental data. Appropriate statistical tests (ANOVA, Wilcoxon test, Westlake test for model-independent parameters; principal components analysis, Hotelling T2 test for model-dependent parameters) demonstrated the bioequivalence of the two formulations.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center