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Int J Biol Macromol. 2018 Feb;107(Pt B):2211-2216. doi: 10.1016/j.ijbiomac.2017.10.084. Epub 2017 Oct 16.

The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice.

Author information

1
School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, China.
2
School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang 212013, Jiangsu, China.
3
School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang 212013, Jiangsu, China.
4
School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd., Zhenjiang 212013, Jiangsu, China. Electronic address: yangliuqing@ujs.edu.cn.
5
School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, China. Electronic address: wuxy@ujs.edu.cn.

Abstract

Previous study revealed that Se-GP11 could exhibited its antitumor activity by improving the immune functions. 5-Fu, as a chemotherapeutic drugs, can kill many immune cells in addition to tumor cells. Accordingly, the enhanced antitumor and reduced toxicity of Se-GP11 on 5-Fu were estimated in this study. The results demonstrated that Se-GP11 could evidently increase the antitumor activity of 5-Fu. Furthermore, Se-GP11 could enhance the immune functions during the tumor inhibition process of 5-Fu for increasing the cytokines secretion (IL-2 and TNF-α) and immune organs weights. In addition, Se-GP11 could reduce the toxicity of 5-Fu on liver by improving the hematological and biochemical parameters and up-regulating the SOD activities and down-regulating the MDA levels. Taken together, the results indicated that Se-GP11 may develop as an auxiliary preparation to chemical antitumor drugs.

KEYWORDS:

Attenuation; Grifola frondosa; Polysaccharide; Selenium-enriched; Synergism

PMID:
29042284
DOI:
10.1016/j.ijbiomac.2017.10.084
[Indexed for MEDLINE]

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