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J Comp Eff Res. 2017 Oct;6(7):583-589. doi: 10.2217/cer-2016-0091. Epub 2017 Oct 17.

Targeted identification of adverse events in coronary artery disease patients based on patient-reported outcomes.

Author information

1
Heart Center, Kuopio University Hospital, Kuopio, Finland.
2
Research Centre for Comparative Effectiveness & Patient Safety (RECEPS), School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
3
School of Pharmacy, Pharmacoeconomics & Outcomes Research Unit (PHORU), University of Eastern Finland, Kuopio, Finland.
4
School of Medicine, University of Eastern Finland, Kuopio, Finland.
5
Kuopio University Hospital, Administration, Kuopio, Finland.
6
University of Helsinki and Helsinki University Hospital, Administration, Helsinki, Finland.

Abstract

AIM:

Can focusing the adverse events search to patients with poor patient-reported outcome help in targeting adverse event detection?

PATIENTS & METHODS:

Coronary artery revascularization patients of the Kuopio University Hospital from June 2012 to August 2014 categorized into those with clinically significant improvement (15D score change ≥0.015, n = 81) or deterioration (change ≥-0.015, n = 64) in post-intervention health-related quality of life.

RESULTS:

Major complications (27 vs 9%, p = 0.004) or post-intervention infections (16 vs 5%, p = 0.031) were more common among those with deteriorated score. They also tended to have more cardiovascular (19 vs 9%, p = 0.071) and minor complications (16 vs 7%, p = 0.118).

CONCLUSION:

Patient-reported outcomes may potentially help in targeting the adverse events search so that a larger number of adverse events can be identified for efficient learning from them.

KEYWORDS:

cardiology/cardiovascular; comparative safety; patient-reported outcomes

PMID:
29039972
DOI:
10.2217/cer-2016-0091

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