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Biosci Microbiota Food Health. 2017;36(4):141-145. doi: 10.12938/bmfh.16-029. Epub 2017 Jul 4.

Polysaccharide from black currant (Ribes nigrum L.) stimulates dendritic cells through TLR4 signaling.

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Research Laboratories for Health Science & Food Technologies, Kirin Company, Ltd., 1-17-1 Namamugi, Tsurumi-ku, Yokohama 230-8628, Japan.
Marketing Department, Mercian Corporation, 4-10-2 Nakano, Nakano-ku, Tokyo 164-0001, Japan.
Research Laboratories for Wine Technologies, Kirin Company, Ltd., 4-9-1 Johnan, Fujisawa 251-0057, Japan.


Black currant (Ribes nigrum) has various beneficial properties for human health. In particular, polysaccharide from black currant was found to be an immunostimulating food ingredient and was reported to have antitumor activity in a mouse model. We named it cassis polysaccharide (CAPS). In a previous study, CAPS administration caused tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production in vitro and in vivo, but the immunological mechanism of CAPS was not demonstrated. In this study, we revealed the CAPS immunostimulating mechanism in vitro. First, we found that CAPS activated dendritic cells (DCs). Second, we investigated whether it depends on Toll-like receptor 4 (TLR4) and myeloid differentiation primary response (Myd). We concluded that CAPS stimulates DCs through Myd88 depending TLR4 signaling and activates Th1-type cytokine release.


black currant; dendritic cell; immunostimulation; polysaccharide

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