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Autoimmun Rev. 2017 Dec;16(12):1265-1269. doi: 10.1016/j.autrev.2017.10.011. Epub 2017 Oct 14.

Rheumatic diseases and autoimmune vascular dementia.

Author information

1
IRCCS Orthopedic Institute of Galeazzi, Milan, Italy. Electronic address: atzenifabiola@hotmail.com.
2
Rheumatology Department, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
3
Division of Rheumatology, University of Padoa, Italy.
4
Orthopedic and Trauma Unit, Santissima Trinità Hospital, Cagliari, Italy.
5
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Department of Neurology, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
6
Department of Clinical Neurosciences, Villa San Benedetto Menni, Hermanas Hospitalarias, FoRiPsi, Albese con Cassano, Como, Italy.
7
Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Department of Neurology, Robert and Martha Harden Chair in Mental and Neurological Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel.
8
Rheumatology Unit, L. Sacco University Hospital, Milan, Italy.

Abstract

Vascular dementia (VD) comes second after Alzheimer's disease (AD) as a cause of impaired cognition. VD is not a specific nosological entity, but rather a syndrome encompassing a number of diseases caused by impaired supply of blood to the brain. Systemic autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis and antiphospholipid syndrome (APS) can be associated with dementia. VD is often related to the presence of traditional cardiovascular risk factors, but it may also be associated with a host of disorders affecting the brain blood vessels, neuronal cells, or both. It is important to entertain in the differential diagnosis of VD, to recognize and to cure them accurately in order to preserve life's quality of our patients.

KEYWORDS:

Autoimmunity; Central pain; Rheumatic diseases; Vascular dementia; Vasculitis

PMID:
29037904
DOI:
10.1016/j.autrev.2017.10.011
[Indexed for MEDLINE]

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