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Trends Genet. 2018 Jan;34(1):41-53. doi: 10.1016/j.tig.2017.09.010. Epub 2017 Oct 13.

Caenorhabditis elegans Dosage Compensation: Insights into Condensin-Mediated Gene Regulation.

Author information

1
Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA.
2
Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA. Electronic address: se71@nyu.edu.

Abstract

Recent work demonstrating the role of chromosome organization in transcriptional regulation has sparked substantial interest in the molecular mechanisms that control chromosome structure. Condensin, an evolutionarily conserved multisubunit protein complex, is essential for chromosome condensation during cell division and functions in regulating gene expression during interphase. In Caenorhabditis elegans, a specialized condensin forms the core of the dosage compensation complex (DCC), which specifically binds to and represses transcription from the hermaphrodite X chromosomes. DCC serves as a clear paradigm for addressing how condensins target large chromosomal domains and how they function to regulate chromosome structure and transcription. Here, we discuss recent research on C. elegans DCC in the context of canonical condensin mechanisms as have been studied in various organisms.

KEYWORDS:

X chromosome; condensin; cooperation; dosage compensation; gene regulation; genome organization

PMID:
29037439
PMCID:
PMC5741500
DOI:
10.1016/j.tig.2017.09.010
[Indexed for MEDLINE]
Free PMC Article

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