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BMC Geriatr. 2017 Oct 16;17(1):237. doi: 10.1186/s12877-017-0635-9.

Feasibility of a multi-modal exercise program on cognition in older adults with Type 2 diabetes - a pilot randomised controlled trial.

Author information

1
Menzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia. michele.callisaya@utas.edu.au.
2
Stroke and Aging Research Group, Department of Medicine, Southern Clinical School, Monash University, Clayton, Victoria, Australia. michele.callisaya@utas.edu.au.
3
Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia. michele.callisaya@utas.edu.au.
4
Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Melbourne, Victoria, Australia.
5
Menzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.
6
Medical School, Faculty of Health and Medical Sciences, University of Western Australia Fremantle Hospital, Fremantle, Western Australia, Australia.
7
Stroke and Aging Research Group, Department of Medicine, Southern Clinical School, Monash University, Clayton, Victoria, Australia.
8
Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
9
Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
10
Department of Medicine, Frankston Hospital, Peninsula Health, Melbourne, Victoria, Australia.

Abstract

BACKGROUND:

Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain structure in people with T2D.

METHODS:

A 6-month pilot parallel RCT of a progressive aerobic- and resistance-training program versus a gentle movement control group in people with T2D aged 50-75 years (n = 50) at the University of Tasmania, Australia. Assessors were blinded to group allocation. Brain volume (total, white matter, hippocampus), cortical thickness and white matter microstructure (fractional anisotrophy and mean diffusivity) were measured using magnetic resonance imaging, and cognition using a battery of neuropsychological tests. Study design was assessed by any changes (during the pilot or recommended) to the protocol, recruitment by numbers screened and time to enrol 50 participants; randomisation by similarity of characteristics in groups at baseline, adherence by exercise class attendance; safety by number and description of adverse events and retention by numbers withdrawn.

RESULTS:

The mean age of participants was 66.2 (SD 4.9) years and 48% were women. There were no changes to the design during the study. A total of 114 people were screened for eligibility, with 50 participants with T2D enrolled over 8 months. Forty-seven participants (94%) completed the study (23 of 24 controls; 24 of 26 in the intervention group). Baseline characteristics were reasonably balanced between groups. Exercise class attendance was 79% for the intervention and 75% for the control group. There were 6 serious adverse events assessed as not or unlikely to be due to the intervention. Effect sizes for each outcome variable are provided.

CONCLUSION:

This study supports the feasibility of a large scale RCT to test the benefits of multi-modal exercise to prevent cognitive decline in people with T2D. Design changes to the future trial are provided.

TRIAL REGISTRATION:

ANZCTR 12614000222640 ; Registered 3/3/2014; First participant enrolled 26/6/2014, study screening commenced 1/9/2014; Australian and New Zealand Clinical Trial Registry.

KEYWORDS:

Cognition; Dementia; Exercise; Intervention; MRI brain; Type 2 diabetes

PMID:
29037162
PMCID:
PMC5644140
DOI:
10.1186/s12877-017-0635-9
[Indexed for MEDLINE]
Free PMC Article

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