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J Clin Invest. 2017 Nov 1;127(11):3918-3920. doi: 10.1172/JCI97042. Epub 2017 Oct 16.

Cannabis in fat: high hopes to treat obesity.

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Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine.
Yale University School of Medicine, and.
Department of Comparative Medicine, Program of Integrative Cell Signaling and Neurobiology of Metabolism, New Haven, Connecticut, USA.


Cannabinoid receptor type-1 (CB1) is known to have a substantial impact on the regulation of energy metabolism via central and peripheral mechanisms. In this issue of the JCI, Ruiz de Azua and colleagues provide important insights into the regulation of adipocyte physiology by CB1. Mice with adipocyte-specific deletion of the CB1-encoding gene had an overall improved metabolic profile in addition to reduced body weight and total adiposity. These changes were associated with an increase in sympathetic tone of the adipose tissue and expansion of activated macrophages, both of which occurred prior to changes in body weight, lending support to a causal relationship between loss of CB1 in adipocytes and systemic metabolic changes. This work identifies adipocyte CB1s as a potential novel peripheral target for affecting systemic metabolism with diminished CNS effects.

[Available on 2018-11-01]
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