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IEEE Trans Neural Syst Rehabil Eng. 2018 Jan;26(1):233-243. doi: 10.1109/TNSRE.2017.2763130. Epub 2017 Oct 16.

An Embedded Real-Time Processing Platform for Optogenetic Neuroprosthetic Applications.

Abstract

Optogenetics offers a powerful new approach for controlling neural circuits. It has numerous applications in both basic and clinical science. These applications require stimulating devices with small processors that can perform real-time neural signal processing, deliver high-intensity light with high spatial and temporal resolution, and do not consume a lot of power. In this paper, we demonstrate the implementation of neuronal models in a platform consisting of an embedded system module and a portable digital light processing projector. As a replacement for damaged neural circuitry, the embedded module processes neural signals and then directs the projector to optogenetically activate a downstream neural pathway. We present a design in the context of stimulating circuits in the visual system, but the approach is feasible for a broad range of biomedical applications.

PMID:
29035219
DOI:
10.1109/TNSRE.2017.2763130
[Indexed for MEDLINE]

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