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Adv Healthc Mater. 2017 Dec;6(23). doi: 10.1002/adhm.201700733. Epub 2017 Oct 16.

Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation.

Author information

1
Department of Bioengineering, University of Pittsburgh, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
2
Department of Chemical Engineering, University of Pittsburgh, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
3
Department of Chemical Engineering, Department of Orthopedic Surgery, Ri.MED Foundation, 427 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.
4
Department of Chemical Engineering, Department of Bioengineering, Department of Ophthalmology, Department of Immunology, Department of Pharmaceutical Sciences, The McGowan Institute for Regenerative Medicine, 940 Benedum Hall 3700 O'Hara Street, Pittsburgh, PA, 15261, USA.

Abstract

Dry eye disease, age-related macular degeneration, and uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, proinflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies are developed to either address the symptoms or abate the underlying cause of these diseases. Herein, the challenges to deliver drugs to the relevant location in the eye for each of these diseases are reviewed along with current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment.

KEYWORDS:

age-related macular degeneration; drug delivery; dry eye disease; therapeutics; uveitis

PMID:
29034584
PMCID:
PMC5915344
DOI:
10.1002/adhm.201700733
[Indexed for MEDLINE]
Free PMC Article

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