Send to

Choose Destination
Comput Diffus MRI (2016). 2016 Oct;2016:49-59. doi: 10.1007/978-3-319-54130-3_4. Epub 2017 May 13.

Denoising Diffusion-Weighted Images Using Grouped Iterative Hard Thresholding of Multi-Channel Framelets.

Author information

School of Information and Electrical Engineering, Hunan University of Science & Technology, Xiangtan, China.
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, U.S.A.
Data Processing Center, Northwestern Polytechnical University, Xi'an, China.
Department of Psychiatry & Behavioral Sciences, Stanford University, U.S.A.
Beijing International Center for Mathematical Research, Peking University, Beijing, China.


Noise in diffusion-weighted (DW) images increases the complexity of quantitative analysis and decreases the reliability of inferences. Hence, to improve analysis, it is often desirable to remove noise and at the same time preserve relevant image features. In this paper, we propose a tight wavelet frame based approach for edge-preserving denoising of DW images. Our approach (i) employs the unitary extension principle (UEP) to generate frames that are discrete analogues to differential operators of various orders; (ii) introduces a very efficient method for solving an 0 denoising problem that involves only thresholding and solving a trivial inverse problem; and (iii) groups DW images acquired with neighboring gradient directions for collaborative denoising. Experiments using synthetic data with noncentral chi noise and real data with repeated scans confirm that our method yields superior performance compared with denoising using state-of-the-art methods such as non-local means.


Diffusion-weighted imaging; multi-channel framelets; noncentral chi noise; sparse representation; tight wavelet frames

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center