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Front Cell Infect Microbiol. 2017 Sep 29;7:435. doi: 10.3389/fcimb.2017.00435. eCollection 2017.

Rab GTPases in Immunity and Inflammation.

Author information

1
Host-Pathogen Interactions in Tuberculosis Laboratory, Francis Crick Institute, London, United Kingdom.

Abstract

Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By controlling the formation, transport and fusion of intracellular organelles, Rab GTPases serve as master regulators of membrane trafficking. In this review, we discuss the cellular and molecular mechanisms by which Rab GTPases regulate immunity and inflammation.

KEYWORDS:

Rab GTPase; inflammation; innate immunity; macrophages; phagosomes

PMID:
29034219
PMCID:
PMC5627064
DOI:
10.3389/fcimb.2017.00435
[Indexed for MEDLINE]
Free PMC Article

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