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Biomed Pharmacother. 2017 Dec;96:563-571. doi: 10.1016/j.biopha.2017.10.021. Epub 2017 Oct 13.

Quinic acid inhibits vascular inflammation in TNF-α-stimulated vascular smooth muscle cells.

Author information

1
Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea.
2
Department of Herbal Medicine Resources, Kangwon National University, Samcheok 25913, Republic of Korea.
3
Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Jeonju 54874, Republic of Korea.
4
Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Republic of Korea. Electronic address: sckang@khu.ac.kr.

Abstract

Atherosclerosis is a chronic inflammatory disease, and the increased expression of adhesion molecules on vascular smooth muscle cells contributes to the progression of vascular disease. Quinic acid (QA) has been shown to possess radioprotection, anti-neuroinflammatory, and anti-oxidant activities; however, an anti-vascular inflammatory effect has not been reported. This study investigated the effect of QA on the expression of vascular cell adhesion molecule-1 (VCAM-1) stimulated by TNF-α in MOVAS cells. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2h with QA (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. QA inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. Our results indicate that QA inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of QA to inhibit vascular inflammation such as atherosclerosis.

KEYWORDS:

MOVAS; Quinic acid; TNF-α; Vascular cell adhesion molecule-1; Vascular inflammation

PMID:
29032340
DOI:
10.1016/j.biopha.2017.10.021
[Indexed for MEDLINE]

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