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Pharmacol Rep. 2017 Oct;69(5):1113-1119. doi: 10.1016/j.pharep.2017.05.002. Epub 2017 May 13.

Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia.

Author information

1
Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland. Electronic address: beata.nowak@umed.wroc.pl.
2
Department of Pharmacology, Wroclaw Medical University, Wrocław, Poland.
3
Division of Biomedical Engineering and Experimental Mechanics, Wroclaw University of Technology, Wrocław, Poland.
4
Department of Endocrinology, Diabetology and Isotopes Therapy, Wroclaw Medical University, Wrocław, Poland.
5
Department of Pathomorphology, Wroclaw Medical University, Wrocław, Poland.
6
Department of Epizootiology and Clinic of Birds and Exotic Animals, The Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Wrocław, Poland.
7
Division of Pathomorphology and Oncological Cytology, Wroclaw Medical University, Wrocław, Poland.

Abstract

BACKGROUND:

Postmenopausal osteoporosis and osteoporotic fractures constitute an increasing problem in developing countries. Kaempferol, isolated from seeds of Cuscuta chinensis, is an active flavonoid inhibiting in vitro osteoclast activity. The aim of the presented research was an assessment of kaempferol effect on estrogen-deficiency-induced bone structure disturbances in rats.

METHODS:

The study was performed on 24 Wistar female rats divided into 3 groups: SHAM - rats undergoing a "sham" surgery, OVX-C - control group of animals that underwent ovariectomy, OVX-K - rats undergoing ovariectomy and receiving kaempferol for 8 weeks (from day 56 to day 112).

RESULTS:

In the OVX-K group, contrary to the OVX-C one, there was no significant decrease in femoral bone mineral density (BMD). A significant increase in Young's modulus was observed in the OVX-K group compared to the OVX-C (15.33±2.51GPa vs. 11.14±1.93GPa, p<0.05). A decreased bone turnover was detected in the OVX-K group. Tissue volume ratio (BV/TV) and trabecular bone perimeter were increased in the OVX-K group compared to the OVX-C one (0.241±0.037 vs. 0.170±0.022, p<0.05 and 15.52±2.78mm vs. 9.67±3.07mm, p<0.05, respectively).

CONCLUSION:

Kaempferol has a beneficial influence on estrogen-deficiency-induced disturbances of bone structure in rats.

KEYWORDS:

Bone histomorphometry; Bone mechanical properties; Bone mineral density (BMD); Bone turnover; Kaempferol; Rats

PMID:
29031689
DOI:
10.1016/j.pharep.2017.05.002
[Indexed for MEDLINE]

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