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Ocul Surf. 2018 Jan;16(1):31-44. doi: 10.1016/j.jtos.2017.10.001. Epub 2017 Oct 12.

Neuropathic pain and dry eye.

Author information

1
Miami Veterans Administration Medical Center, USA; Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA. Electronic address: agalor@med.miami.edu.
2
Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
3
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA.
4
Miami Veterans Administration Medical Center, USA; Physical Medicine and Rehabilitation, University of Miami, USA.
5
Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA.
6
Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami Miller School of Medicine, Miami, FL, USA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA; John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.

Abstract

Dry eye is a common, multifactorial disease currently diagnosed by a combination of symptoms and signs. Its epidemiology and clinical presentation have many similarities with neuropathic pain outside the eye. This review highlights the similarities between dry eye and neuropathic pain, focusing on clinical features, somatosensory function, and underlying pathophysiology. Implications of these similarities on the diagnosis and treatment of dry eye are discussed.

KEYWORDS:

Dry eye; Genetics; Inflammation; Nerve sensitization; Neuropathic pain; Treatment

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