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Genomics. 2017 Oct 12. pii: S0888-7543(17)30115-5. doi: 10.1016/j.ygeno.2017.10.003. [Epub ahead of print]

dbGAPs: A comprehensive database of genes and genetic markers associated with psoriasis and its subtypes.

Author information

1
Biomedical Informatics Centre, National Institute of Pathology - ICMR, New Delhi, India.
2
Synthetic Biology Laboratory, School of Biotechnology, JNU, New Delhi, India.
3
Biomedical Informatics Centre, National Institute of Pathology - ICMR, New Delhi, India. Electronic address: akjain@instpath.gov.in.

Abstract

Psoriasis is a systemic hyperproliferative inflammatory skin disorder, although rarely fatal but significantly reduces quality of life. Understanding the full genetic component of the disease association may provide insight into biological pathways as well as targets and biomarkers for diagnosis, prognosis and therapy. Studies related to psoriasis associated genes and genetic markers are scattered and not easily amendable to data-mining. To alleviate difficulties, we have developed dbGAPs an integrated knowledgebase representing a gateway to psoriasis associated genomic data. The database contains annotation for 202 manually curated genes associated with psoriasis and its subtypes with cross-references. Functional enrichment of these genes, in context of Gene Ontology and pathways, provide insight into their important role in psoriasis etiology and pathogenesis. The dbGAPs interface is enriched with an interactive search engine for data retrieval along with unique customized tools for Single Nucleotide Polymorphism (SNP)/indel detection and SNP/indel annotations. dbGAPs is accessible at http://www.bmicnip.in/dbgaps/.

KEYWORDS:

Gene annotations; Gene ontology; Psoriasis; Psoriasis associated genes; SNP detection tool; Single nucleotide polymorphism

PMID:
29031638
DOI:
10.1016/j.ygeno.2017.10.003
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