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Adv Chronic Kidney Dis. 2017 Sep;24(5):280-288. doi: 10.1053/j.ackd.2017.08.003.

Epidemiology of Acid-Base Derangements in CKD.

Author information

1
University of Rochester School of Medicine and Dentistry, Rochester, NY; and Albert Einstein College of Medicine, Bronx, NY.
2
University of Rochester School of Medicine and Dentistry, Rochester, NY; and Albert Einstein College of Medicine, Bronx, NY. Electronic address: matthew.abramowitz@einstein.yu.edu.

Abstract

Acid-base disorders are in patients with chronic kidney disease, with chronic metabolic acidosis receiving the most attention clinically in terms of diagnosis and treatment. A number of observational studies have reported on the prevalence of acid-base disorders in this patient population and their relationship with outcomes, mostly focusing on chronic metabolic acidosis. The majority have used serum bicarbonate alone to define acid-base status due to the lack of widely available data on other acid-base disorders. This review discusses the time course of acid-base alterations in CKD patients, their prevalence, and associations with CKD progression and mortality.

KEYWORDS:

Acidosis; Alkalosis; Epidemiology; Mortality; Renal insufficiency

PMID:
29031354
PMCID:
PMC5659723
DOI:
10.1053/j.ackd.2017.08.003
[Indexed for MEDLINE]
Free PMC Article

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