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Clin Neurophysiol. 2017 Nov;128(11):2286-2291. doi: 10.1016/j.clinph.2017.08.028. Epub 2017 Sep 20.

Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson's disease.

Author information

1
Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
2
Department of Neurosurgery, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
3
MRC Brain Network Dynamics Unit and Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom.
4
Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité Campus Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin School of Mind and Brain, Charité - Universitätsmedizin Berlin, Berlin, Germany; NeuroCure, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address: andrea.kuehn@charite.de.

Abstract

OBJECTIVES:

To investigate the long term association of subthalamic beta activity with parkinsonian motor signs.

METHODS:

We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8months post-operatively using the implantable sensing enabled Activa PC+S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest. Beta (13-35Hz) peak amplitudes were extracted, compared across time points and correlated with UPDRS-III hemibody scores.

RESULTS:

Peaks in the beta frequency band (13-35Hz) in the OFF medication state were found in all hemispheres. Mean beta activity was significantly suppressed by levodopa at all recorded time points (P<0.007) and individual beta power amplitude correlated with parkinsonian motor impairment across time points and dopaminergic states (pooled data; ρ=0.25, P<0.001).

CONCLUSIONS:

Our results indicate that beta-activity is correlated with parkinsonian motor signs over a time period of 8months.

SIGNIFICANCE:

Beta-activity may be a chronically detectable biomarker of symptom severity in PD that should be further evaluated under ongoing DBS.

KEYWORDS:

Basal ganglia; Beta oscillations; Deep brain stimulation; Local field potentials; Subthalamic nucleus

PMID:
29031219
PMCID:
PMC5779610
DOI:
10.1016/j.clinph.2017.08.028
[Indexed for MEDLINE]
Free PMC Article

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