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J Diabetes. 2018 Apr;10(4):328-337. doi: 10.1111/1753-0407.12614. Epub 2017 Dec 11.

Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial.

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Physical Education Department, Metabolism, Nutrition, and Exercise Laboratory, Londrina State University, Londrina, Brazil.
Physical Education Department, Exercise Physiology Laboratory, Faculty of Physical Education, University of Campinas, Campinas, Brazil.
Department of Pathology, Botucatu School of Medicine, São Paulo State University, Botucatu, Brazil.
Exercise and Nutrition Metabolism Center from the Department of Public Health, Botucatu School of Medicine, São Paulo State University, Botucatu, Brazil.
Center for Research in Health Sciences, University of Northern Parana, Londrina, Brazil.
Clinical Analyses Laboratory, Londrina State University, Londrina, Brazil.
Exercise and Health Laboratory, Interdisciplinary Centre for the Study of Human Performance, Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal.



This study analyzed the effects of a 12-week resistance training (RT) program without dietary interventions on metabolic syndrome (MetS) components and inflammatory biomarkers in older women.


Fifty-three older women (mean [±SD] age 70.4 ± 5.7 years; mean body mass index 26.7 ± 4.0 kg/m2 ) were randomly assigned to a training group (TG; n = 26) that performed 12 weeks of an RT program or a control group (CG; n = 27) that did not perform any type of physical exercise over the same period. Body composition (dual energy X-ray absorptiometry), muscular strength (one-repetition maximum tests), blood pressure (BP), and blood sample measurements were performed before and after intervention.


After the 12-week period, there were significantly reductions (P < 0.05) in glucose levels (-20.4% vs -0.3%), waist circumference (-1.5% vs +2.0%), and systolic BP (-6.2% vs +0.9%), and complete normalization of MetS prevalence (18% at baseline vs. 0% after 12-weeks RT) in the TG. Moreover, C-reactive protein and tumor necrosis factor-α concentrations decreased in the TG (-28.6% and -21.6%, respectively), but increased in the CG (+34.5% and +13.3%, respectively). In addition there were positive improvements in the MetS Z-score in the TG but not CG (-21.6% vs +13.3%, respectively).


The results suggest that a 12-week RT program seems to effectively reduce MetS components and inflammatory biomarkers in older women, regardless of dietary intervention. The RT-induced adaptations in body composition and inflammatory biomarkers appear to be related to healthy adaptations in risk factors for MetS.


body composition; low-grade inflammation; randomized controlled trial; strength training; 低度炎症; 力量训练; 身体组份; 随机对照试验

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